Recent Advances in Point-of-Care (POC) Devices in the Diagnosis of Blood Infection Diseases (Sepsis) based on Electrochemical Biosensors

Document Type : Review

Authors

1 School of Life Science Engineering, College of Interdisciplinary Science and Technology, University of Tehran, Tehran, Iran

2 School of Intelligent Systems, College of Interdisciplinary Science and Technology, University of Tehran, Tehran, Iran

10.30491/jmm.2024.1006736.1226

Abstract

As a potentially life-threatening immune response, sepsis is often caused by the body's interaction with various microorganisms, including bacteria, viruses, and fungi. This phenomenon is one of the leading causes of death worldwide, posing numerous challenges for medical professionals. Therefore, rapid diagnosis and effective treatment implementation with appropriate antibiotics are crucial for improving treatment outcomes. However, this issue is challenging, as current molecular detection methods are mostly time-consuming, expensive, and reliant on advanced equipment and specialized personnel. Considering that every moment of delay in sepsis diagnosis and treatment increases the likelihood of death, it is imperative to utilize diagnostic devices capable of reducing the time required to identify the onset of infection until appropriate therapy is administered. In this regard, advanced testing tools capable of detecting clinically relevant biomarkers play a significant role. Electrochemical biosensors, offering advantages such as high sensitivity, rapid response, compact size, and low cost, are well-suited to meet clinical needs. This review article examines the current status of electrochemical-based point-of-care detection platforms and their limitations for diagnosing and monitoring sepsis. It also discusses future directions and solutions to enhance and expand these technologies.

Keywords

Journal of Military Medicine
Volume 26, Issue 4 - Serial Number 128
November and December 2024
Pages 2375-2394

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