The Impact of Vanadium-Zinc Supplementation Combined with Two Different Intensities of Aerobic Exercise on Modulation of Lipid Profile and Insulin Resistance in Rats Fed High-Fructose Corn Syrup

Document Type : Original Research

Authors

1 Department of Exercise Physiology, Faculty of Sport Sciences, University of Mazandaran, Babolsar, Iran

2 Department of Basic Sciences, Faculty of Veterinary Medicine, University of Tabriz, Tabriz, Iran

Abstract

Background and Aim: Insulin resistance is a metabolic disorder marked by insufficient tissue response to insulin secretion and hyperinsulinemia. This metabolic abnormality plays a crucial role in the pathogenesis of many diseases. It appears that changes in lifestyle, such as participating in exercise activity and consumption of non-medicinal supplements, will ameliorate this condition; therefore, the present study aims to investigate the effects of aerobic exercise and vanadium-zinc supplementation on body composition, lipid profile, and insulin resistance index in fructose-fed rats.
Methods: In this experimental study, 56 male wistar rats were randomly assigned to one of seven groups (eight rats per group); 1) Normal control (NC), 2) Fructose control (FC), 3) Fructose + Moderate-intensity continuous training (FIT), 4) Fructose + High-intensity interval training (FCT), 5) Vanadium-zinc supplement (FS), 6) Moderate-intensity continuous training + Vanadium-zinc supplement (FSIT), and 7) High-intensity interval training + Vanadium-zinc supplement (FSCT). The protocol of moderate intensity continuous training consisted of running for 12 to 54 min at a velocity of 12 to 20 m/min on a motorized treadmill with a 5% to 15% incline (weeks 1 to 8); also High-intensity interval training performed 3 min bouts at 40 m/min, interspersed by 3 min active recovery at a running velocity of 20 m/min on a motorized treadmill with a 5% to 15% incline. Supplement groups received 10 mg/kg/day of vanadium-zinc through oral gavage. Body composition and serum levels of lipid profile, glucose, insulin, and HOMA-IR index were measured before and 48 hours after the final session of the training program in a fast state.
Results: Eight weeks of aerobic exercise and vanadium-zinc supplementation significantly improved body composition (P=0.0001), insulin resistance (P=0.0001), and lipid profile indices (P≤0.05). Aerobic exercise combined with vanadium-zinc supplementation has the most significant impact on the modulation of serum insulin resistance, lipid profile, and, inguinal and retroperitoneal fat tissue (P≤0.05).
Conclusion: Findings suggest that vanadium-zinc supplementation combined with aerobic exercise can be effective in improving metabolic conditions and body composition.

Keywords

Journal of Military Medicine
Volume 25, Issue 3 - Serial Number 121
July and August 2023
Pages 1880-1891

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