Aims. Mitochondrial DNA (mtDNA) sequence analysis of the hypervariable control region has been shown to be an effective tool for personal identification. The high copy, resistance to degradation, short size (as compared with nuclear DNA) and maternal mode of inheritance make mtDNA analysis particularly useful when old age or degradation of biological sample prohibits the detection and analysis of nuclear DNA. Methods. This study reports mtDNA polymorphisms in HV1 of the non coding D-loop region from 30 persons (10 unrelated families in 3 sequential maternal generations). Results. 32 polymorphic nucleotide positions were found in this region. The sequence of HV1 and its polymorphism were completely similar in each family. The average number of nucleotide differences between families in this region was 5.2 nucleotides. Conclusion. We will expect approximately 5 nucleotide differences in HV1 sequence in two unknown, unrelated samples and no difference in maternal related samples. This method specially can be used for identification of war victims.
Morovvati S., , & Modarresi M., (2022). Evaluation of Mitochondrial DNA HV1 Region: an Approach to Personal Identification via Maternal Generation. Journal of Military Medicine, 7(2), 113-119.
MLA
Morovvati S.; Modarresi M.. "Evaluation of Mitochondrial DNA HV1 Region: an Approach to Personal Identification via Maternal Generation". Journal of Military Medicine, 7, 2, 2022, 113-119.
HARVARD
Morovvati S., , Modarresi M., (2022). 'Evaluation of Mitochondrial DNA HV1 Region: an Approach to Personal Identification via Maternal Generation', Journal of Military Medicine, 7(2), pp. 113-119.
VANCOUVER
Morovvati S., , Modarresi M., Evaluation of Mitochondrial DNA HV1 Region: an Approach to Personal Identification via Maternal Generation. Journal of Military Medicine, 2022; 7(2): 113-119.
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