Is War Injury a Risk Factor of Hepatitis D in Hepatitis B Patients?

Document Type : Original Research

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Abstract

Aim. War injury is reported as a risk factor of hepatitis B and C, and it is suggested to be also a risk factor for hepatitis D. This study was conducted with the aim of assessing the correlation between war injury and hepatitis D in hepatitis B patients. Methods. In this observational (cross - sectional) study, 280 HBsAg positive subjects were divided to a group with the history of war injury (n = 12) and a group without such history (n = 268). Two groups were compared by the means of frequency of hepatitis D (Anti HDV Ab) and other risk factors including history of blood transfusion, surgery, intravenous drug abuse, dentistry interventions, traditional phlebotomy, tattoo and endoscopy. Results. 3 subjects with the history of war injury (25%) and 13 subjects without such history (4.9%) had hepatitis D. Odds ratio of HDV in subjects with the history of war injury versus those without such history was 5.10 (95% CI = 1.3 - 20.5). History of blood transfusion was reported more in patients with war injury than those without such history (p=0.002). History of surgery, intravenous drug abuse, dentistry interventions, traditional phlebotomy, tattoo and endoscopy was not different in two groups (p>0.05). Conclusion. Although this study had a low sample size in the group with history of war injury, and confounding effect of blood transfusion and sex is possible, this study reports history of war injury as a possible risk factor for hepatitis D. Further studies will help to clarify more results. If such study replicates our results, screening of HDV in war injured veterans will be helpful.

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